Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis
نویسندگان
چکیده
منابع مشابه
Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis.
BACKGROUND A precise temporal and spatial regulation of gene expression is necessary to achieve neural tube closure. Med12, a subunit of the mediator complex, can bind transcription factors and modulate expression of their target genes. Med12 is essential during early mouse development and is important for neural tube closure. METHODS We have made use of a mouse line carrying a conditional nu...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2010
ISSN: 1542-0752
DOI: 10.1002/bdra.20693